high) can influence the likelihood of MOGAD diagnosis. The type of cell-based assay used to evaluate for MOG-IgG (fixed vs. The detection of MOG-IgG in the serum (and sometimes CSF) confirms the diagnosis in patients with compatible clinical-MRI phenotypes, but false positive results are occasionally encountered, especially with indiscriminate testing of large unselected populations. Characteristic MRI features have been described that increase the diagnostic suspicion (e.g., perineural optic nerve enhancement, spinal cord H-sign, T2-lesion resolution over time) and help discriminate from MS and AQP4+NMOSD, despite some overlap. A relapsing course is observed in approximately 50% of patients. The clinical manifestations of MOGAD are heterogeneous, ranging from isolated optic neuritis or myelitis to multifocal CNS demyelination often in the form of acute disseminated encephalomyelitis (ADEM), or cortical encephalitis. Over the last decade, several studies have helped delineate the characteristic clinical-MRI phenotypes of the disease, allowing distinction from aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) and multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is the most recently defined inflammatory demyelinating disease of the central nervous system (CNS). 8Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.7Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.6Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.5Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.4Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States. 3Department of Neurology and Center for Multiple Sclerosis and Autoimmune Neurology Mayo Clinic, Rochester, MN, United States.2Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.1Neurology Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. Chen 3,4 Sara Mariotto 5 Giulia Fadda 6 Alessandro Dinoto 5 A. Elia Sechi 1 Laura Cacciaguerra 2,3 John J.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |